Molecular Mechanisms on the Selectivity Enhancement of Ascorbic Acid, Dopamine, and Uric Acid by Serine Oligomers Decoration on Graphene Oxide: A Molecular Dynamics Study

The selectivity in the simultaneous detection of ascorbic acid (AA), dopamine (DA), and uric acid (UA) has been an open problem in the biosensing field.Many surface modification methods were carried out for glassy carbon electrodes (GCE), including the use of graphene oxide and amino acids as a selective layer.In this work, molecular dynamics (MD)

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New achievements in vaccine development

Vaccines have made Pullovers a major contribution to global public health, including the eradication of one deadly disease, small pox, and the near eradication of another, poliomyelitis.In the future, vaccination will be expected to eliminate the remaining childhood infectious diseases.Development of new, safe and effective adjuvants is also an imp

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Variability in Loss of Multiple Enzyme Activities Due to the Human Genetic Variation P284T Located in the Flexible Hinge Region of NADPH Cytochrome P450 Oxidoreductase

Cytochromes P450 located in the endoplasmic reticulum require NADPH cytochrome P450 oxidoreductase (POR) for their catalytic activities.Mutations in POR cause multiple disorders in humans related to the biosynthesis of steroid hormones and also affect drug-metabolizing cytochrome P450 activities.Electron transfer in POR occurs from NADH to FAD to F

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